Ribosomes ( /ˈraɪbəˌsoʊm, -boʊ-/) are macromolecular machines, found within all cells, that perform biological protein synthesis (mRNA translation). Ribosomes link amino acids together in the order specified by the codons of messenger RNA (mRNA) molecules to form polypeptide chains. Ribosomes consist of two major components: the small and large ribosomal subunits. Each subunit consists of one or more ribosomal RNA (rRNA) molecules and many ribosomal proteins (RPs or r-proteins).[1][2][3] The ribosomes and associated molecules are also known as the translational apparatus.
“The book succeeds by not limiting discussion to today's most popular model organisms and trendy molecules, but by including many organisms that have virtually disappeared from meeting presentations. The book contains 54 chapters separated into five parts that cover embryology, cell biology, molecular biology, evolution, and a brief overview of remaining questions. Chapter authors were encouraged to cite the primary literature in lieu of reviews, which should ensure that the book stands as a lasting resource for current and future developmental biologists. Intended for researchers, teachers, and students, some chapters will be accessible to all, while others will only be readily understood by advanced readers....It is a treat to skip through the chapters of this book. Readers will find it worth the price, and I thank Stern and Cold Spring Harbor Laboratory Press for compiling this snapshot of gastrulation studies at the turn of the 21st century.” —The Quarterly Review of Biology
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VMF conceived and oversaw the project. MDR designed and performed all the experiments, including the animal experiments, the laser capture microdissection, the immunohistochemistry and the molecular analyses. TM and CF performed all the bioinformatics and statistical analyses. GP contributed with IPA analysis. JGF oversaw laser capture microdissection, miRNA profiling and contributed to project conceiving. ES oversaw the animal experiments. MDR, LL, MLP and EM contributed to the molecular analyses. MS and GL performed the cell biology experiments and cytofluorimetric analysis. MGD and EP collected the tissue samples of CRC patients and performed histological analyses. VMF and MDR interpreted data and wrote the manuscript. TM, CF, MLP, GP, ES, JGF and ALV discussed the results and assisted in revisions. All authors read and approved the final manuscript 2ff7e9595c
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